WAYS TO IMPROVE THE QUALITY OF LIFE OF PATIENTS WITH METABOLIC SYNDROME: A SYSTEMATIC REVIEW

Abstract

Actuality. Improvement in health-related quality of life may be a key characteristic and measure of the effectiveness of metabolic syndrome interventions. Lifestyle changes today are one of the leading means of treating this syndrome. Previous studies on the impact of lifestyle changes on quality of life have not provided a clear answer to this question, so a systematic review is appropriate to clarify the evidence. The purpose. The purpose of the systematic review was to evaluate the impact of lifestyle interventions in adults with metabolic syndrome (MS) on health-related quality of life (HRQoL) and its physical, mental and social dimensions. Materials and methods. Inclusion criteria were: randomized clinical trials (RCTs), the study was conducted in adults (both sexes) who had at least four criteria for MS, a lifestyle intervention, and measurement of HRQoL using a validated questionnaire. Exclusion criteria included studies of a different design than RCTs. Based on the Cochrane Collaboration risk of bias tool, only two RCTs were identified as having a high risk of bias. Databases used were PubMed, Cochrane Library, EMBASE and Google Scholar. Seven RCTs were selected for a systemic review with 1108 study participants. Research results. The results of the systematic review were mixed. Small improvements were found in physical HRQoL measures in the physical activity lifestyle interventions, but inconsistent changes occurred in one of the RCTs, with better results in the control group. Quality of life related to mental health had a positive effect over time, but without a significant difference in the comparison groups. The overall score was not calculated in most RCTs, meaning changes were not determined. Conclusion. The findings suggest that lifestyle interventions in the RCTs selected for this systematic review do not provide insight into these effects on HRQoL and this issue requires further research..